Web10 sep. 2024 · The findings suggested that the median probability of the hyperinflammatory phenotype was 0.03. Further analysis indicated that the prevalence of … Web8 dec. 2024 · Background Two molecular phenotypes of the acute respiratory distress syndrome (ARDS) with divergent clinical trajectories and responses to therapy have been identified. Classification as “hyperinflammatory” or “hypoinflammatory” depends on plasma biomarker profiling. Differences in pulmonary biology underlying these phenotypes are …
The discovery of biological subphenotypes in ARDS: a
Web25 aug. 2024 · Four phenotypes were found, and the conservative fluid-management strategy significantly improved the 90-day cumulative mortality compared with the liberal … Web24 mrt. 2024 · Under-recognition of ARDS may stem in part from the considerable clinical heterogeneity observed among patients who meet standard ARDS criteria. The syndrome may be triggered, for example, by pulmonary or extrapulmonary sepsis, aspiration, trauma, blood product transfusion, or pancreatitis. Pulmonary infiltrates can be focal or diffuse. shantell monee lyons
Prevalence of phenotypes of acute respiratory distress syndrome …
Web9 feb. 2024 · Over the last decade, the management of acute respiratory distress syndrome (ARDS) has made considerable progress both regarding supportive and pharmacologic … Web12 apr. 2024 · 4.1 Acute lung inflammation 4.1.1 ARDS. IFN-dependent acute lung inflammation shows an indivisible relationship with STING. Silica, smoking, and pathogenic infection can induce cell death and release self-DNA, leading to the activation of the cGAS-STING pathway and driving IFN-dependent sterile inflammation (16, 77, 91).ARDS … WebWith latent class analysis of data from clinical trials, Calfee et al have identified two phenotypes of ARDS in the general population, 12 the “hyperinflammatory” phenotype is characterized by inflammation (including a higher concentration of serum IL-6, IL-8), increased mortality and decreased ventilator-free days. shantell montel knight barbados